Using a new magnetically separable nanocatalyst in the synthesis of [1,2,4]triazolo quinazolinone derivatives

The quinazolinones derivatives as nitrogen-containing heterocycles has drawn a huge consideration because of their biological activities and various applications in pharmaceutical industries and their important role in research, medicinal and industrial societies. [1,2]. in this study Immobilized NaHSO4 on core/shell phenylene bridged Periodic mesoporous organosilica magnetic nanoparticles (Fe3O4@Ph-PMO-NaHSO4) as a new acidic magnetically separable nanocatalyst was successfully prepared in three steps: (i) preparation of Fe3O4 nanoparticles by a precipitation method, (ii) synthesis of an organic-inorganic periodic mesoporous organosilica structure with phenyl groups on the surface of Fe3O4 magnetic nanoparticles (MNPs) and (iii) finally adsorption of NaHSO4 on periodic mesoporous organosilica (PMO) network and it was used as a a new magnetically separable solid acid nanocatalyst for the synthesis of [1,2,4]triazolo quinazolinone [3].