Evidences of Allosteric Interactions in the DNA Molecule at Nano-scale

In this paper, we try to explain the origin of the anomalous elastic behavior of nanometer-sized DNA molecules, which has been observed in an all-atom molecular dynamic simulation [A. K. Mazur, Phys. Rev. Lett. , 2007]. It will be shown that, this anomalous behavior is a consequence of nonlocal interactions between DNA base pairs. A nonlocal harmonic elastic rod model will be proposed. In this model, the roll angles of the different base pairs are coupled together. This model can successfully describe the elastic behavior of short DNA molecules.

کلیدواژه ها:

DNA ، Elasticity ، Allostery ، Long-range interactions