HN-00160211_Effects of Nutraceuticals and Natural Compounds on Plasma ApolipoproteinB: A Review of Evidence

Cardiovascular diseases (CVDs) are the number one cause of death globally, taking an estimated 17.9 million lives each year. Apolipoprotein B (Apo B) is the primary apolipoproteinof chylomicrons, VLDL, IDL, and LDL particles. Indeed, Apo B is the main components of all major atherogenic lipoprotein. It is proposed to measure Apo B concentration as a valid and reliable index to predict andindicate CVD risk than measurement of LDL. A growing body of evidence indicated that herbal medicine, particularly phytochemicals prevent and treat non-communicable diseases particularly CVD, diabetes mellitus, hypertension, non-alcoholic fatty liver disease (NAFLD). Although the effect of natural compound and phytochemicals on CVD, and some of its risk factors including dyslipidemia, were investigated previously, to the authors knowledge, the effect of these natural products, including herbal medicine and functional foods on Apo B, as one the most important parameters involved in CVD has not investigated yet. Thus, in this review, we aimed to evaluate the effect of bioactive nutraceuticals and natural compounds on plasma Apo B concentrations. Results show that some of the medicinal plants and nutraceuticals including xuezhikang, berberine, olive oil, nuts and flaxseed could be used as a complementary medicine to reduce plasma Apo B. Thus, herbal medicine could be considered as safe, available and accessible andinexpensive natural products to prevent and treat CVD and its related indices.

کلیدواژه ها:

Apolipoprotein B ، Cardiovascular diseases ، Herbal medicine ، Nutraceuticals