HN-00470022_The Effect of L-carnitine Supplementation on Blood Pressure in Patients with Type 2 Diabetes: A Randomized, Double-blind, placebo-controlled Trial

Introduction: Diabetic patients with hypertension are at a high risk of cardiovascular complications. The present study determined the effect of oral L-carnitine supplementation on blood pressure in patients with type 2 diabetes mellitus (T2DM).Methods: In this randomized, double-blind, placebo-controlled trial, 70 patients with T2DM in the age range of 41 to 75 years were randomly allocated to intervention (n = 35), who received 1000 mg/day L-carnitin and placebo (n =35) groups, who received similar dose 1000 mg/day wheat starch as placebo for 12 weeks. The systolic and diastolic blood pressures, mean arterial blood pressure and pulse pressure were examined before and after the intervention.Results: Sixty-four participants completed the study. At the end of the study period, L-carnitine-treated diabetics, compared with the placebo group, did not show significant difference in SBP (-1/14±2/45 mmHg vs. -2/42±2/79 mmHg), DBP (-3/2±1/94 mmHg vs. -6±2/30 mmHg), MAP (-2/51±1/84 mmHg vs. -4/80±2/11 mmHg) and PP (2/05±2/23 mmHg vs. 3/57±2/73 mmHg).Conclusion: The oral supplementation of L-carnitine 1000 mg/day does not affect blood pressure after 12 weeks of treatment in diabetes patient.

کلیدواژه ها:

diabetes ، L-carnitine ، blood pressure ، hypertension