Interactio ns of Glutathione tripeptide with gold cluster: Influence o f intramolecular hydrogen bond on complex ation beha vior

Understanding the nature of interaction between metal nanoparticles and biomolecules has been important in the develop ment and design of sen sors. Among various n anoparticles, gold nanoparticles hav e attracted m uch attenti on in chemi stry and material scienc e because of their good biocompatib ility, facile synthesis, a nd conjugation to a variety of bim olecular lig ands. Glutathione –mo dified gold nano surfaces were considered for specific protein bin ging. Ligand exchange between th e Glutathion e -Au nanoparticles with thiolated oligonucle otides has been examined by Kornbe ry and co-w orkers. Recently, the de velopment of a nanopa rticle-based drug deliv ery and release system using Glutathione as the releasin g agent has been shown to be via ble. Howev er, interparticle interactions of glutathione and metal particles remai n elusive.

کلیدواژه ها:

Glutathione tripeptide ، Gold nanocluster ، Intramolecular hydrogen bond ، AIM theory ، NBO analysis